Nsaale Herbal Cough Syrup 200ml

Description:

Nsaale Herbal Cough Syrup is a scientifically inspired natural formulation designed to provide relief from coughs, chest congestion and soothe irritated throats. This syrup combines the expectorant, demulcent, and antimicrobial properties of Eucalyptus spp., Curcuma Longa and Musa x paradisiaca (banana) extracts.

Mechanism of Action:

• Expectorant (Eucalyptus spp.): The volatile oils in eucalyptus, particularly eucalyptol (1,8-cineole), act as an expectorant by stimulating the respiratory tract's mucous glands. This increased fluid production thins and loosens mucus, making it easier to cough up and clear from the airways.  
• Demulcent (Musa x paradisiaca): Banana extracts, rich in mucilage, provide a soothing demulcent effect. They form a protective layer over irritated mucous membranes in the throat and respiratory tract, relieving discomfort and reducing irritation.
• Antimicrobial (Eucalyptus spp., Curcuma Longa): Extracts possesses antimicrobial properties, which may help to combat certain respiratory pathogens contributing to cough and congestion. The compounds present in the extract can inhibit the growth of some bacteria and viruses.  

Active Organic Compounds:

Eucalyptol,  Alisol F,  Dotriaconytl ethyl ether,  Benzoic acid Silver 1+ salt, Picolinyl 18-methyl 7 eicosenoate, Propanoic acid, N-methyladrenaline, Alanine, 4-(3-methoxyl), 19-epoxyandrostane-8-9-dione.

List of excipients;

Sodium Benzoate.

Indications:

Nsaale Herbal Cough Syrup is indicated for the relief of coughs, chest congestion, and sore throats associated with respiratory infections.

Dosage and Administration:

Adults: 20ml, Children (5-12 years): 10ml, Children (1-4 years): 5ml, Children under 1 years: 2.5ml, Three times (X3) a day or as a prescribed by a physician.

Shake well before use.

Drug Interactions:

No adverse effects have been reported regarding the simultaneous use along with other medications.

Warnings & Precautions:

Pregnancy & Lactation

Nsaale Herbal Cough Syrup contains all-natural formulations which are generally recognized as safe (GRAS) when administered orally. No adverse side effects have been reported by pregnant and breastfeeding individuals though they should exercise caution and take the appropriate dosage as excessive consumption can lead to toxicity and mild side effects.

Side Effects:

Over dosing may cause some angina chest pain, mild diarrhea and anaphylaxis which stop once intake is stopped. Seek medical advice and take caution if you’re allergic to the components.

If cough worsens or persists for more than 7 days, or is accompanied by fever, rash, or persistent headache, consult a healthcare professional.

Storage:

Store at room temperature, away from direct sunlight. Keep out of reach of children. Keep the bottle tightly closed.

Key Ingredients & Their Mechanisms of Action MoA:

• Eucalyptus spp.: The volatile oils in eucalyptus, specifically eucalyptol (1,8-cineole), act as an expectorant by stimulating the respiratory tract's mucous glands. This increases fluid production, which thins and loosens mucus, making it easier to cough up and clear from the airways. It also reduces pain, swelling, and inflammation via immune modulation and exhibits antibacterial and cough suppressant actions. Eucalyptus's expectorant action directly addresses chest congestion by facilitating mucus clearance, while its anti-inflammatory and analgesic properties provide symptomatic relief for sore throats and general respiratory discomfort.  
• Curcuma Longa (Turmeric):. Its antimicrobial and anti-inflammatory properties are beneficial for combating respiratory pathogens and reducing inflammation in the respiratory tract, contributing to cough and congestion relief.  
• Musa x paradisiaca (Banana) extracts: Banana extracts, rich in mucilage, provide a soothing demulcent effect. They form a protective layer over irritated mucous membranes in the throat and respiratory tract, which helps relieve discomfort and reduce irritation. This demulcent action directly soothes irritated mucous membranes, providing immediate relief for sore throats and reducing the irritation that can trigger coughing.  
• Alisol F: Alisol F exhibits anti-inflammatory potential by inhibiting LPS-induced NO production in macrophages and regulating the production of inflammatory cytokines like TNF-α, IL-1β, and IL-6 via the MAPK/STAT3/NFκB pathway. This anti-inflammatory action is highly relevant for reducing inflammation associated with respiratory infections.  
• Dotriaconytl ethyl ether:  Dotriacontanyl ethyl ether, when used in a cough syrup, would primarily function as an emollient for the throat and respiratory passages. By forming a thin, stable film, it could help soothe irritation and provide a lubricating effect, reducing the friction that contributes to coughing. This physical barrier may also help to minimize moisture loss from the mucosal linings, which can alleviate dryness and provide a more comfortable sensation in the throat, potentially reducing the urge to cough. It does not act as a bronchodilator, expectorant, or cough suppressant that targets the cough reflex; its benefit is solely through its conditioning and protective properties on the irritated tissues.  
• Benzoic acid Silver 1+ salt: Benzoic acid is an antimicrobial food additive that is fungistatic and can bind amino acids, reducing ammonia levels. It is used in combination to treat oropharyngeal pain, mouth infections, throat infections, and dry cough. Its antimicrobial properties can help combat pathogens in the respiratory tract, and its analgesic effects contribute to sore throat relief.  
• Picolinyl 18-methyl 7 eicosenoate:  is a highly specialized molecule primarily recognized in analytical chemistry for its use in identifying the precise structure of complex fatty acids via mass spectrometry;  its potential to be hydrolyzed into its constituent fatty acid. This fatty acid, if released and absorbed, offer indirect support through its potential to integrate into cell membranes of respiratory tissues, influencing local immune responses or providing a very subtle emollient-like effect to soothe irritated mucosal linings.
• Propanoic acid: Propionic acid, a short-chain fatty acid, has anti-inflammatory and anti-proliferative properties. It modulates gene expression epigenetically by inhibiting histone deacetylases, affecting apoptosis, inflammation, and immune function. It has shown beneficial immunoregulatory and neuroprotective effects, boosting regulatory T cells and reducing pro-inflammatory responses. These anti-inflammatory and immunomodulatory effects are relevant for reducing respiratory tract inflammation.  
• N-methyladrenaline:  N-methyladrenaline, also known as epinephrine or adrenaline, functions as a potent neurotransmitter and hormone by binding to and activating various adrenergic receptors (α1​,α2​,β1​,β2​,β3​) found throughout the body. Upon binding, it triggers distinct intracellular signaling cascades via G proteins, leading to widespread physiological responses characteristic of the "fight or flight" mechanism. These effects include increased heart rate and contractility, vasoconstriction (in most vascular beds) or vasodilation (in skeletal muscle), bronchodilation, and glucose mobilization, all aimed at preparing the body for immediate action.
• Alanine, 4-(3-methoxyl): Alanine is a non-essential amino acid involved in sugar and acid metabolism, immunity, and energy for muscle tissue, brain, and central nervous system. It can be converted to glucose by the liver, playing a role in blood sugar balance. A derivative, Alanine, 3-(3-formyl-4-methoxyphenyl)-, hydrochloride, DL-, is used in pharmaceutical development. 
• 19-epoxyandrostane-8-9-dione: This compound has demonstrated anti-inflammatory, anti-apoptotic, and anti-infective properties. These properties are relevant for combating infections and reducing inflammation in the respiratory tract.