Each Product-Specific Mechanisms of Action

1. Nsaale Antiseptic Solution NDA Reg. No: THA 1132

Therapeutic Indications: Nsaale Antiseptic Solution is indicated for comprehensive wound management. It promotes quicker wound healing by enhancing hemostasis and phagocytosis. It provides rapid relief from inflammations, itching, and pain. It also instantly neutralizes foul odors from putrid wounds and is effective for various types of wounds, inflammations, and allergic reactions causing itching.  

Key Ingredients & Their Mechanism of Action MoA:

• Eucalyptus spp plant blends:. Its primary therapeutic roles in this product are anti-inflammatory, antimicrobial, and analgesic.  
• Anthraquinone: Anthraquinones, such as rhodoptilometrin, promote wound healing by inducing cell regeneration, increasing cell migration and proliferation of fibroblasts, and enhancing oxidative phosphorylation (OXPHOS) in cells. They increase the expression of proteins crucial for tissue repair, like focal adhesion kinase (FAK), fibronectin, and type I collagen. They also contribute to ridding the wound of contaminants and bacteria, and support re-epithelization, which forms a physical barrier against microbial invasions. The detailed description of anthraquinone's effect on fibroblast proliferation, collagen production, and cell migration provides a clear and direct mechanism for its role in "quicker wound healing." This moves beyond a general statement to specific cellular and molecular processes.  
• Euclanone: A compound related to clove and often associated with Eucalyptus, has various properties, including antimicrobial, antifungal, and anticancer effects. Its anticancer action is thought to involve the generation of reactive oxygen species (ROS), leading to mitochondrial permeability transition and apoptosis. It also inhibits prostaglandin synthesis, contributing to its pain-reducing effects.   
• Carvenone: Carvenone, or related compounds like carvone and carveol, exhibit multiple pharmacological properties, including antibacterial, antifungal, anti-inflammatory, and antioxidant activities. Specifically, carveol has shown excellent bactericidal activity against Staphylococcus aureus and a rapid bactericidal effect against Escherichia coli. Carvenone's (or related compounds') direct bactericidal activity against common wound pathogens like S. aureus and E. coli provides a clear and direct mechanism for its antiseptic function in wound management. This is a crucial contribution to preventing and treating wound infections.
• Methyl Stearate: Methyl stearate functions as a nonionic surfactant, emulsifier, and stabilizer, enhancing the solubility of other chemicals. It offers several benefits to the skin, primarily acting as a skin conditioning agent and emollient. Its oily and waxy nature allows it to form a protective barrier on the skin's surface, which helps to prevent moisture loss, thereby combating dryness and irritation. This emollient property contributes to a smoother, softer skin texture, making it a valuable ingredient in Nsaale Antiseptic Solution designed to enhance skin hydration, Wound healing and maintain its overall health.

Table 1: Nsaale Antiseptic Solution - Key Ingredients, Therapeutic Indications, and Mechanisms of Action

Key Ingredient	Primary Therapeutic Role in Product	Mechanism of Action (MoA)	Relevant Snippet IDs
Eucalyptus spp. plant blends	Anti-inflammatory, Antimicrobial, Analgesic	Modulates immune response; inhibits pro-inflammatory cytokines; exhibits broad-spectrum antimicrobial activity; analgesic and antinociceptive effects.
Anthraquinone	Wound Healing (Cell Regeneration, Proliferation, Migration), Antiseptic, Re-epithelization Support	Induces cell regeneration; increases cell migration and proliferation of fibroblasts; enhances oxidative phosphorylation; increases expression of FAK, fibronectin, and type I collagen; supports re-epithelization.
Euclanone	Antimicrobial, Antifungal, and Anticancer effects	Its anticancer action is thought to involve the generation of reactive oxygen species (ROS), leading to mitochondrial permeability transition and apoptosis. It also inhibits prostaglandin synthesis, contributing to its pain-reducing effects.
Carvenone	Antimicrobial (antibacterial, antifungal), Anti-inflammatory, Antioxidant	Exhibits antibacterial, antifungal, anti-inflammatory, and antioxidant activities; carveol shows bactericidal activity against S. aureus and E. coli.
Methyl Stearate	Excipient (Enhances Formulation, Stability)	Functions as a nonionic surfactant, emulsifier, and stabilizer, enhancing the solubility of other chemicals.

2. Nsaale Ointment  NDA Reg. No. THA1143

Therapeutic Indications: Nsaale Ointment is indicated for relieving acne, dark spots, eczema, tinea, dermatitis, bleached skin, inflammations, and bacterial and fungal skin infections. It is also used in chemoprevention or chemotherapy during wound and burn healing to avoid scar tissue formation by preventing fibrosis of collagen fibers and promoting normal parenchymal tissue growth.  

Key Ingredients & Their Mechanisms of Action MoA:

• Eucalyptol (1,8-cineole):. Its primary therapeutic roles in this product are anti-inflammatory, antimicrobial, and analgesic.  
• Alpha-Terpineol: Terpineol has demonstrated excellent bactericidal activity against Staphylococcus aureus. Its primary therapeutic role in this product is antibacterial.  
• Alpha tocopherol (Vitamin E): Vitamin E is a well-known antioxidant and possesses anti-inflammatory properties. It helps protect cells from oxidative stress and can modulate inflammatory responses, which is beneficial for skin health and healing. Its primary therapeutic roles in this product are antioxidant and anti-inflammatory.  
• D-limonene:  A natural compound found abundantly in citrus peels, exhibits a diverse range of beneficial biological activities, primarily through its antioxidant properties where it neutralizes harmful free radicals and boosts the body's natural defense enzymes. It also acts as an anti-inflammatory agent by reducing pro-inflammatory molecules. In the context of cancer, D-limonene triggers programmed cell death (apoptosis) in cancerous cells, halts their growth by arresting the cell cycle, and inhibits signaling pathways that promote tumor development and spread. Furthermore, it demonstrates antimicrobial effects by disrupting the cell membranes of bacteria and fungi, and can enhance the absorption of other substances through the skin.
• Linalool:. It also shows antibacterial and antifungal properties. Its primary therapeutic roles in this product are anti-inflammatory, antioxidant, antibacterial, and antifungal.  
• Beta sitosterol: Beta sitosterol exhibits anti-cancer, anti-oxidant, anti-bacterial, and anti-inflammatory effects. It specifically attenuates atopic dermatitis-like skin lesions by down-regulating TSLP, reducing inflammatory cell infiltration, and decreasing levels of histamine, IgE, and IL-4. It also inhibits mast cell-derived caspase-1 activation and blocks the caspase-1 and nuclear factor-κB (NF-κB) signaling pathways, thereby reducing TNF-α production. Beta sitosterol's specific mechanism of down-regulating TSLP and inhibiting NF-κB pathways provides a highly relevant and detailed explanation for its efficacy in conditions like eczema and dermatitis. This demonstrates a targeted pharmacological effect beyond general anti-inflammation.  
• Eugenol:. Its primary therapeutic roles in this product are antimicrobial, anti-inflammatory, and analgesic.  
• Lilial: Lilial is  widely used in cosmetics, personal care products, and household items to impart a strong, fresh, floral scent, particularly reminiscent of lily of the valley.
• Coumarin:  Coumarin, a natural compound with a sweet aroma, exhibits a variety of biological activities with diverse mechanisms of action. Its most recognized role, particularly for derivatives like warfarin, involves antagonizing Vitamin K, which prevents blood clotting by disrupting the synthesis of essential clotting factors. Beyond this, coumarins demonstrate anticancer effects by inducing programmed cell death in cancer cells, halting their growth, and inhibiting tumor spread. They also possess anti-inflammatory properties by reducing pro-inflammatory mediators and acting as antioxidants to neutralize harmful free radicals.

Table 2: Nsaale Ointment - Key Ingredients, Therapeutic Indications, and Mechanisms of Action

Key Ingredient	Primary Therapeutic Role in Product	Mechanism of Action (MoA)	Relevant Snippet IDs
Eucalyptol (1,8-cineole)	Anti-inflammatory, Antimicrobial, Analgesic	Modulates immune response; inhibits pro-inflammatory cytokines; exhibits broad-spectrum antimicrobial activity; analgesic and antinociceptive effects.
Alpha-Terpineol	Antibacterial	Demonstrates excellent bactericidal activity against Staphylococcus aureus.
Alpha tocopherol (Vitamin E)	Antioxidant, Anti-inflammatory	Protects cells from oxidative stress; modulates inflammatory responses.
D-limonene	Exhibits a diverse range of beneficial biological activities e.g Antioxidant, Antimicrobial,  Anti-cancer	In the context of cancer, D-limonene triggers programmed cell death (apoptosis) in cancerous cells, halts their growth by arresting the cell cycle, and inhibits signaling pathways that promote tumor development and spread.
Linalool	Anti-inflammatory, Antioxidant, Antibacterial, Antifungal	Acts on inflammatory process and oxidative stress; possesses antibacterial and antifungal properties.
Beta sitosterol	Anti-inflammatory (especially for eczema/dermatitis), Anti-bacterial, Anti-cancer, Antioxidant	Attenuates atopic dermatitis-like skin lesions by down-regulating TSLP; reduces inflammatory cell infiltration; inhibits mast cell-derived caspase-1 activation; blocks caspase-1 and NF-κB signaling pathways.
Eugenol	Antimicrobial, Anti-inflammatory, Analgesic	Possesses potent antioxidant, anti-inflammatory, and antimicrobial properties; scavenges free radicals; suppresses pro-inflammatory pathways.
Lilial	Fragrance	To impart a strong, fresh, floral scent, particularly reminiscent of lily of the valley.
Coumarin	Antagonizing Vitamin K, Anti-cancer, Antioxidant,  Anti-inflammatory	Exhibits a variety of biological activities with diverse mechanisms of action.

3. Nsaale Herbal Soap with Activated Charcoal  NDA Reg. No. THA 1342

Therapeutic Indications: This soap is formulated to offer a detoxifying effect to the skin, aiding in the excretion of toxins, excess oil, chemicals, and impurities. It aims to promote healthier, more youthful, and invigorated skin through its natural detoxifying, antioxidant, antiseptic, and antimicrobial properties. It is indicated for relieving bleached skin, acne, skin neoplasms, dermatitis, inflammations, and bacterial and fungal skin infections.  

Key Ingredients & Their Mechanisms of Action MoA:

• Activated Charcoal Powder: Activated charcoal possesses exceptional adsorptive properties due to its vast, porous surface area. This characteristic allows it to attract and bind to pollutants, toxins, excess oils, dirt, impurities, and bacteria from the skin's surface and pores. This physical binding action facilitates deep cleansing, helps control sebum production, prevents pore blockage, and reduces breakouts. Its ability to remove impurities contributes to skin detoxification, purification, and exfoliation by sloughing off dead skin cells, revealing cleaner skin. It also acts as a barrier against environmental pollutants, reducing free radical formation, and its detoxification properties can reduce redness and inflammation. The primary mechanism of adsorption directly contributes to the observed benefits of oil control and acne reduction. By physically removing excess sebum and impurities that clog pores, activated charcoal addresses a fundamental cause of acne and oily skin, establishing a clear link between its adsorptive capacity and its dermatological benefits. 
• Succinic Acid: Succinic Acid works by supporting skin cell energy production and regeneration, helping to repair damage and promote a healthier appearance. It also acts as a mild exfoliant by loosening dead skin cells, possesses antimicrobial properties to inhibit bacterial and fungal growth, and offers anti-inflammatory benefits to soothe irritation.
• 2,3,4,5-tetrafluorobenzyl: Is included for its formulation benefits, such as acting as a stabilizer for other ingredients or as a solvent/carrier to help other active compounds disperse and potentially penetrate the skin more effectively.  
• Tomatidine: Tomatidine primarily functions as an antifungal agent, effectively disrupting the cell membranes of fungi to combat infections like dermatophytes. It also contributes anti-inflammatory effects, helping to calm skin irritation and redness.
• Cyclopentasiloxane decamethyl- (D5) is a silicone that acts as a skin conditioner and emollient. It forms a lightweight, non-greasy film on the skin, enhancing smoothness, trapping moisture to prevent dryness, and providing a silky feel. It also serves as an excellent solvent and carrier for other ingredients in the formulation.
• Acetic Acid trifluoro- is a strong acid likely used in very low concentrations for pH adjustment within the soap formulation. While potent as an exfoliant at higher concentrations, its role in a soap is typically to ensure the product's stability and efficacy by maintaining an optimal pH level, rather than significant direct skin exfoliation.
  
• Salicylic Acid: Salicylic acid acts as a keratolytic agent by causing the cells of the epidermis to slough off more readily, which prevents pores from clogging and allows for new cell growth. It softens and destroys the stratum corneum by increasing endogenous hydration, leading to swelling, softening, and desquamation of the horny layer of the skin. It also possesses weak antifungal and antibacterial activity. Salicylic acid's ability to promote epidermal cell sloughing directly addresses the root cause of clogged pores in acne. This exfoliation prevents the buildup of dead skin cells and sebum, thereby reducing the formation of blackheads and blemishes. Its additional weak antimicrobial activity provides a supplementary benefit against acne-causing bacteria.  

Table 3: Nsaale Herbal Soap with Activated Charcoal - Key Ingredients, Therapeutic Indications, and Mechanisms of Action

Key Ingredient	Primary Therapeutic Role in Product	Mechanism of Action (MoA)	Relevant Snippet IDs
Activated Charcoal Powder	Detoxifying, Deep Cleansing, Oil Control, Exfoliant, Anti-inflammatory (indirect), Antiseptic/Antimicrobial (mechanical)	Adsorbs pollutants, toxins, excess oils, dirt, impurities, and bacteria from skin; helps control sebum; exfoliates dead skin cells; acts as a barrier against environmental pollutants; reduces free radical formation; reduces redness and inflammation.
Succinic Acid	Antimicrobial, Anti-inflammatory, Moisturizing, Antioxidant, Skin Regeneration Support	Inhibits growth of Cutibacterium acnes; modulates inflammatory responses; strengthens skin barrier; protects from free radicals; may inhibit collagen degradation and promote cell regeneration.
Salicylic Acid	Exfoliant, Pore Unclogging, Anti-acne, Weak Antimicrobial	Causes epidermal cells to slough off; softens and destroys stratum corneum; possesses weak antifungal and antibacterial activity.

4. Nsaale Herbal Soap with Turmeric NDA Reg. No. THA 1341

Therapeutic Indications: It works synergistically as a sooth and indicated for relieving acne, dark spots, eczema, dermatitis, inflammations, bacterial and fungal skin infections. Turmeric-specific information suggests protection against acne, insect bites, cuts, and allergies , and relief for dark areas due to eczema.  

Key Ingredients & Their Mechanisms of Action MoA:

• Turmeric Extracts (Curcuma longa): Turmeric, primarily through its active compound curcumin and volatile oils, exhibits potent antioxidant, anti-inflammatory, and broad-spectrum antimicrobial activities. Curcumin disrupts bacterial cell membranes, inhibits bacterial virulence factors and biofilm formation, and interferes with bacterial protein and DNA synthesis, leading to cell death. It also modulates host immune responses by activating macrophages and regulating inflammatory signaling molecules (cytokines, transcription factors, enzymes), thereby ameliorating bacterial infections and reducing inflammation. Turmeric also demonstrates antiviral and antifungal activity (e.g., against  Candida albicans). Its astringent properties further contribute to skin protection. Turmeric’s ability to disrupt bacterial cell structures and modulate host immune responses provides a dual-action mechanism for treating skin infections and inflammation. This comprehensive approach ensures both direct pathogen control and symptomatic relief, which is crucial for conditions like eczema and dermatitis. The strong emphasis on turmeric's anti-inflammatory, antimicrobial, and antioxidant properties across multiple Nsaale products highlights a core botanical strategy. This suggests that the company leverages well-researched compounds with broad therapeutic utility, maximizing the versatility of their product line.  
• L-Heptacosanol, a long-chain fatty alcohol, acts primarily as an emollient and skin conditioning agent. It forms a protective barrier on the skin, reducing moisture loss and making the skin feel smoother and softer. It also helps to thicken and stabilize product formulations.
• Glycerin is a powerful humectant that draws moisture from the environment into the skin, significantly boosting hydration. It also helps to strengthen the skin's natural barrier function, preventing water loss and enhancing skin health.
• Citronellol primarily functions as a fragrance component, providing a pleasant floral or citrusy scent. It also exhibits mild antimicrobial properties by disrupting microbial cell membranes, though it can be a skin sensitizer for some individuals. 
• Geraniol is mainly used as a fragrance component, imparting a rose-like scent. It also offers antimicrobial benefits by damaging microbial cell membranes, and possesses some antioxidant activity, though it can also be a skin sensitizer. 
• Dodecanoic Acid (Lauric Acid) is highly valued for its strong antimicrobial properties, particularly against bacteria and viruses, by disrupting their lipid membranes. As a fatty acid, it also acts as an emollient to soften the skin and helps in the cleansing action of soaps. 
• Methyl Stearate, a fatty acid methyl ester, serves as an emollient and skin conditioning agent. It creates a light, non-greasy film that helps to smooth and soften the skin while reducing moisture loss, and improves product spreadability. 
• Hexadecanoic Acid Methyl Ester (Methyl Palmitate) is another fatty acid methyl ester that acts as an emollient and skin conditioner. It helps to improve skin softness and smoothness by forming a protective layer that minimizes moisture evaporation, also enhancing the product's texture. 
• L-alpha-Terpineol is a monoterpene alcohol known for its significant antimicrobial (antibacterial and antifungal) activity, achieved by disrupting microbial cell membranes. It also offers anti-inflammatory and some antioxidant benefits, and contributes a fresh, floral scent. 
• Tetrapentacontane, 1,54-dibromo- primarily functions as an emollient due to its very long hydrocarbon chain, providing a rich, occlusive feel that helps to reduce moisture loss and improve skin conditioning.

Table 4: Nsaale Herbal Soap with Turmeric - Key Ingredients, Therapeutic Indications, and Mechanisms of Action

Key Ingredient	Primary Therapeutic Role in Product	Mechanism of Action (MoA)	Relevant Snippet IDs
Turmeric Extracts (Curcuma longa)	Anti-inflammatory, Antimicrobial (antibacterial, antifungal, antiviral), Antioxidant, Astringent	Disrupts bacterial cell membranes; inhibits bacterial virulence factors and biofilm formation; interferes with bacterial protein and DNA synthesis; modulates host immune responses; activates macrophages; regulates inflammatory signaling molecules; exhibits antiviral and antifungal activity.

5. Nsaale Herbal Lotion  NDA Reg. No. THA 1343

Therapeutic Indications: Nsaale Herbal Lotion is formulated for supporting and restoring normal skin functions by providing soothing relief and nourishment. It boosts the excretory function of the skin by unclogging sweat and oil gland pores, offering a detoxifying effect by helping the skin excrete toxins, excess oil, chemicals, and impurities through sweat, leading to body homeostasis. It helps relieve acne, dark spots, eczema, tinea, skin neoplasms, dermatitis, bleached skin, inflammations, bacterial and fungal skin infections. It is also used in chemoprevention or chemotherapy during wound and burn healing to avoid scar tissue formation by preventing fibrosis of collagen fibers.  

Key Ingredients & Their Mechanisms of Action MoA:

• Eucalyptus spp: Eucalyptus oil, particularly its main component 1,8-cineole, is effective in reducing pain, swelling, and inflammation by modulating the immune response and inhibiting the production of pro-inflammatory cytokines like TNF-α, IL-1β, and IL-6. It also exhibits broad-spectrum antimicrobial activity, including antibacterial, antiviral (against HSV-1/2), and antifungal effects. Its analgesic and antinociceptive effects contribute to pain alleviation. The detailed mechanism of 1,8-cineole inhibiting pro-inflammatory cytokines provides a specific molecular basis for Eucalyptus's anti-inflammatory action, moving beyond a general statement to specific cellular and molecular processes, which is crucial for a pharmacology report.  
• Curcuma longa (Turmeric):. Its primary therapeutic roles in this product are anti-inflammatory, antimicrobial, and antioxidant.  
• Syzygium aromaticum (Clove): Clove contains bioactive compounds such as eugenol, α-humulene, and β-caryophyllene, which demonstrate potent antioxidant and anti-inflammatory properties by scavenging free radicals, modulating calcium channels, and suppressing pro-inflammatory pathways, including NF-κB. It also possesses significant antimicrobial (antibacterial, antifungal, antiviral) and anticarcinogenic activities. The combination of Eucalyptus, Turmeric, and Clove in this lotion exemplifies a synergistic botanical blend. Each botanical contributes distinct yet overlapping anti-inflammatory, antimicrobial, and antioxidant pathways , resulting in a more robust and comprehensive therapeutic effect across a wide spectrum of skin conditions. This multi-target approach is a common strategy in natural product medicine.  
• Squalene is a natural polyunsaturated hydrocarbon that is a major component of human sebum (10-16%). Its primary mechanism of action revolves around its role as a natural emollient and skin barrier component. Squalene integrates into the skin's lipid barrier, helping to reduce transepidermal water loss (TEWL) and maintain skin hydration. This action supports the skin's natural barrier function, protecting it from environmental aggressors and preventing dryness. It also acts as a natural antioxidant on the skin's surface, helping to neutralize free radicals generated by UV exposure and other environmental stressors, thus preventing oxidative damage to skin cells. Its inherent compatibility with skin lipids makes it highly effective for moisturizing and restoring skin suppleness without feeling heavy or greasy.
• Phenanthrenequinone:  Due to its mechanisms involving oxidative stress generation and disruption of cellular processes, some studies explore its use for antimicrobial effects against certain pathogens or in targeted therapies against skin cancer cells. In these specific, controlled contexts, its ability to induce cell damage might be leveraged to eliminate unwanted microbial growth or abnormal cell proliferation on the skin.
• (Z)-gamma-Atlantone is a sesquiterpene ketone found in essential oils, particularly from cedarwood. Its mechanism of action is largely attributed to its antimicrobial and anti-inflammatory properties. It is thought to exert its antimicrobial effects by disrupting the cell membranes of bacteria and fungi, leading to their growth inhibition or death. As an anti-inflammatory agent, it may modulate cellular pathways involved in the inflammatory response, helping to reduce redness and irritation in the skin. Additionally, like many terpenes, it can contribute a characteristic aroma to formulations.
  
• Dodecanoic acid (Lauric acid): Dodecanoic acid is a medium-chain saturated fatty acid with strong antimicrobial properties against bacteria, viruses (especially fat-enveloped), and yeasts. It inhibits bacterial growth by interfering with cell membranes and vital cellular processes, and by binding to enzymes like dihydrolipoamide acetyltransferase and fatty acid synthase. It can also have synergistic effects with other antibiotics. 
• Eicosane:  As an emollient and skin conditioning agent, eicosane forms a non-occlusive film on the skin's surface. This film helps to smooth the skin's texture and reduce rough patches, contributing to a soft and pliable feel. While it doesn't directly add moisture like a humectant (e.g., glycerin), it can help to reduce transepidermal water loss (TEWL) by creating a barrier that slows down the evaporation of water from the skin, thereby indirectly supporting skin hydration and comfort. Additionally, it can function as a solvent for other ingredients within the formulation, aiding in their dispersion and contributing to the overall feel and spreadability of the product.
• Ethyllinalool: The related compound Linalool acts on the inflammatory process and oxidative stress. It also possesses antibacterial and antifungal properties. These general properties  support the lotion's anti-inflammatory, antioxidant, and antimicrobial claims.   
• Hexadecanoic acid methyl ester: This compound has demonstrated significant antimicrobial effects against pathogenic bacteria and possesses antibacterial, anti-inflammatory, and antioxidant properties. It forms a light, non-greasy film on the skin, which helps to reduce moisture evaporation and improve the skin's softness and smoothness. 
• Dodecanoic acid methyl ester, or methyl laurate, is another fatty acid methyl ester derived from lauric acid. Its mechanism of action is primarily as an emollient and skin conditioning agent. Similar to other FAMEs, it helps to create a soft, smooth feel on the skin by forming a light film that reduces water loss. It also functions as a solvent for other lipophilic ingredients in the formulation, aiding in product consistency and spreadability. 
• Octanoic acid methyl ester, or methyl caprylate, is a shorter-chain fatty acid methyl ester. Its mode of action is as an emollient and skin conditioning agent, providing a light, non-greasy feel to the skin while helping to maintain hydration by reducing moisture evaporation. Due to its relatively smaller size, it can contribute to a lighter sensory feel compared to longer-chain esters. It also acts as a solvent and spreading agent in cosmetic formulations. 
• Glycerin is a potent humectant that works by attracting and drawing water from the environment into the skin's outermost layers (stratum corneum). This significantly increases the skin's water content, leading to enhanced hydration. Furthermore, glycerin helps to strengthen and restore the skin's natural barrier function, which is crucial for preventing water loss and protecting against external irritants. Its ability to improve skin hydration also contributes to a smoother and softer skin texture.

Table 5: Nsaale Herbal Lotion - Key Ingredients, Therapeutic Indications, and Mechanisms of Action

Key Ingredient	Primary Therapeutic Role in Product	Mechanism of Action (MoA)	Relevant Snippet IDs
Eucalyptus spp.	Anti-inflammatory, Antimicrobial, Analgesic	Modulates immune response; inhibits pro-inflammatory cytokines; exhibits broad-spectrum antimicrobial activity; analgesic and antinociceptive effects.
Curcuma longa (Turmeric)	Anti-inflammatory, Antimicrobial, Antioxidant	Disrupts bacterial cell membranes; inhibits bacterial virulence factors; modulates host immune responses; exhibits antiviral and antifungal activity.
Syzygium aromaticum (Clove)	Antioxidant, Anti-inflammatory, Antimicrobial, Potential Anticarcinogenic Support	Scavenges free radicals; modulates calcium channels; suppresses pro-inflammatory pathways (e.g., NF-κB); possesses antibacterial, antifungal, and antiviral activities.
Phenanthrenequinone	Antimicrobial	Its ability to induce cell damage might be leveraged to eliminate unwanted microbial growth or abnormal cell proliferation on the skin.
Dodecanoic acid (Lauric acid)	Antimicrobial (antibacterial, antiviral, antifungal)	Interferes with cell membranes and vital cellular processes; binds to enzymes like dihydrolipoamide acetyltransferase and fatty acid synthase; can have synergistic effects with antibiotics.
Eicosane	Emollient, Skin Conditioner	Non-volatile hydrocarbon emollient; provides satiny texture; non-comedogenic; good spreadability; conditions hair and skin.
Ethyllinalool	Potential Anti-inflammatory, Antioxidant, Antimicrobial	(Inferred from Linalool) Acts on inflammatory process and oxidative stress; possesses antibacterial and antifungal properties.
Hexadecanoic acid methyl ester	Antimicrobial, Anti-inflammatory, Antioxidant	Demonstrates antimicrobial effects against pathogenic bacteria; possesses antibacterial, anti-inflammatory, and antioxidant properties.
Octanoic acid methyl ester	Emollient, Skin Conditioner	Fatty acid methyl ester; skin conditioning agent and emollient.

6. Nsaale Body Detoxifier  NDA Reg. No. THA 1339

Therapeutic Indications: Nsaale Body Detoxifier Bio-Syrup is primarily indicated for cleansing the body by eliminating toxins, excess oil, chemicals, and impurities from the blood, particularly through processing in the liver. These toxins are then expelled via the skin, kidneys, intestines, lungs, and lymphatic system during the detoxification process. This action helps in relieving symptoms associated with inflammation, pain, blood clotting, infections, and brain function.  

Key Ingredients & Their Mechanisms of Action MoA:

• Spirostan-6-ol amino:  Functions through a combination of mechanisms primarily inherited from its spirostan steroid backbone and modified by its amino and hydroxyl groups. Its primary actions involve disrupting microbial cell membranes, offering antimicrobial (especially antifungal and antibacterial) benefits by compromising pathogen integrity. It also possess anti-inflammatory properties by modulating cellular pathways and immune responses, thereby reducing skin irritation and redness. Furthermore, like some other steroidal compounds, it potentially support skin barrier function, contributing to improved moisturization.
• 9-Octadecenoic Acid (Oleic Acid): 9-Octadecenoic acid (Oleic Acid) exhibits antioxidant activity. It has potent hypolipidemic effects, significantly decreasing serum triglycerides (TG), total cholesterol (TC), LDL-C, and hepatic TG, potentially by reducing the activity of enzymes like acetyl coenzyme A (CoA) and acetyl transferase 2 (ACAT2) involved in cholesterol metabolism. It also possesses anti-inflammatory, anti-bacterial, and antifungal properties. The hypolipidemic action of 9-Octadecenoic Acid provides a direct and specific mechanism for the product's claim of "eliminating excess oil... from the blood." This establishes a clear cause-and-effect relationship between the compound's known pharmacology and the product's detoxifying indication related to lipids.  
• Arachidonic Acid: Arachidonic acid (AA) is a key omega-6 polyunsaturated fatty acid that links nutrient metabolism to immunity and inflammation. It serves as a precursor for a wide array of highly bioactive metabolites, known as eicosanoids (e.g., prostaglandins, leukotrienes), which are central to triggering and mediating inflammatory responses. AA is released from cell membranes in response to cellular activation signals, including inflammation or infection. Increased levels of certain AA metabolites can lead to inflammatory damage. Arachidonic Acid is primarily known as a precursor to pro-inflammatory mediators. This suggests that the product is not simply reducing inflammation by removing AA, but rather modulating the body's natural inflammatory and immune responses, by influencing the balance of AA metabolites or supporting the resolution phase of inflammation.
• Alpha-D-glucose:  Alpha-D-glucose plays a crucial indirect role in the body's detoxification processes primarily by supplying the energy (ATP and NADPH) required for the liver's intricate Phase I and Phase II detoxification enzymes. These enzymes, particularly the cytochrome P450s in Phase I and various conjugating enzymes in Phase II, are responsible for chemically transforming fat-soluble toxins and metabolic byproducts into more water-soluble forms that can then be safely excreted from the body via urine or bile. Additionally, glucose metabolism through pathways like the pentose phosphate pathway regenerates NADPH, a vital co-factor for the glutathione system and other antioxidant defenses, which are essential for neutralizing reactive oxygen species (ROS) often generated during detoxification and by environmental toxins. Thus, a sufficient and consistent supply of glucose is fundamental to supporting the energetic demands and enzymatic function of the body's natural detoxification machinery.  
• Beta-D-Mannofuranoside:  Beta-D-Mannofuranoside is a specific sugar molecule, a furanose (5-membered ring) form of mannose with a beta anomeric configuration. Unlike glucose, which is a primary energy source, beta-D-mannofuranoside itself is not directly a major energy metabolite in most organisms. Its mode of action is typically as a component of more complex glycans (carbohydrate chains), which play crucial roles in cellular recognition, signaling, and structural integrity. For instance, beta-D-mannopyranosides (the 6-membered ring form, but related) are essential components of N-glycans on proteins, plant beta-mannans, and various pathogen surface antigens. Therefore, beta-D-mannofuranoside, as a building block, participates in the complex enzymatic processes of glycosylation, where it is added to or cleaved from larger biomolecules by specific glycosyltransferases or glycosidases (like beta-mannosidases). This involvement allows it to contribute to the unique structures of glycoconjugates that are vital for host-pathogen interactions, immune responses, cell-cell communication, and maintaining overall biological function. Some derivatives are also used as enzyme substrates in biochemical assays to study the activity of glycosidases.
• Methyl stearate:. Its primary role is as an excipient, enhancing formulation and stability.  
• Tetradecanoic acid: Tetradecanoic acid (myristic acid) does not directly neutralize or eliminate toxins in the body's detoxification processes. Instead, its mode of action is an indirect supportive role, primarily by being incorporated as a lipid anchor for specific proteins in cell membranes, including those in detoxifying organs like the liver. This N-myristoylation helps tether these proteins to membranes, where they often participate in crucial signaling and metabolic pathways. By contributing to healthy cell membrane structure and ensuring adequate cellular energy through its role in metabolism, tetradecanoic acid helps maintain the overall cellular integrity and function essential for the body's natural detoxification systems to operate effectively. 
• N-Hexadecanoic acid: N-hexadecanoic acid (palmitic acid) is a common saturated fatty acid with antibacterial, anti-inflammatory, and antioxidant properties. 
• Dodecanoic acid: Its primary therapeutic role in this product is antimicrobial.  
• Glutaric acid:  In the human body, glutaric acid's intended use is as a normal intermediate in the metabolic breakdown of specific amino acids, particularly lysine, hydroxylysine, and tryptophan. It's part of the intricate series of biochemical reactions that allow the body to extract energy from these protein building blocks and dispose of excess amino acids. Enzymes in the metabolic pathway ensure that glutaric acid is further processed into other compounds, preventing its accumulation and thus maintaining overall metabolic balance and cellular health.  
• Dodecanoic acid methyl ester:. Its primary therapeutic role in this product is antimicrobial.  

 Table 6: Nsaale Body Detoxifier - Key Ingredients, Therapeutic Indications, and Mechanisms of Action

Key Ingredient	Primary Therapeutic Role in Product	Mechanism of Action (MoA)	Relevant Snippet IDs
Spirostan-6-ol amino	anti-inflammatory , Antifungal and Antibacterial	Functions through a combination of mechanisms primarily inherited with disrupting microbial cell membranes
9-Octadecenoic Acid (Oleic Acid)	Hypolipidemic, Antioxidant, Anti-inflammatory, Antimicrobial	Exhibits antioxidant activity; decreases serum TG, TC, LDL-C, and hepatic TG; possesses anti-inflammatory, anti-bacterial, and antifungal properties.
Arachidonic Acid	Modulator of Inflammatory and Immune Responses	Precursor for eicosanoids (pro-inflammatory mediators); released in response to cellular activation signals like inflammation/infection.
Alpha-D-glucose	General Metabolic Support, Cell Protection	Monosaccharide with insulin stimulating effect; can protect cell membranes from toxicity.
Beta-D-Mannofuranoside	Cellular recognition, signaling, and structural integrity	Contribute to the unique structures of glycoconjugates that are vital for host-pathogen interactions, immune responses, cell-cell communication, and maintaining overall biological function.
Methyl stearate	Excipient (Enhances Formulation, Stability)	Nonionic surfactant, emulsifier, and stabilizer.
Tetradecanoic acid	Indirect supportive role	Its mode of action is an indirect supportive role, primarily by being incorporated as a lipid anchor for specific proteins in cell membranes, including those in detoxifying organs like the liver.
N-Hexadecanoic acid	Antibacterial, Anti-inflammatory, Antioxidant	Common saturated fatty acid with antibacterial, anti-inflammatory, and antioxidant properties.
Dodecanoic acid (Lauric acid)	Antimicrobial (antibacterial, antiviral, antifungal)	Interferes with cell membranes; inhibits bacterial growth by binding to enzymes.
Glutaric acid	Normal intermediate in the metabolic breakdown of specific amino acids  particularly lysine, hydroxylysine, and tryptophan.	It's part of the intricate series of biochemical reactions that allow the body to extract energy from these protein building blocks and dispose of excess amino acids.
Dodecanoic acid methyl ester	Antimicrobial (antibacterial, antiviral, antifungal)	Interferes with cell membranes; inhibits bacterial growth by binding to enzymes.

7. Nsaale Antacid Herbal Syrup NDA Reg. No. THA 1340

Therapeutic Indications: Nsaale Antacid Herbal Syrup is formulated from Eucalyptus spp. plant blends to lower hyperchlorhydria (excess stomach acid) levels. It helps relieve symptoms of GERD, stomach ulcers, stomach upset, heartburn, bloating, belching, and constipation. It does not prevent acid production but works to reduce existing levels.  

Key Ingredients & Their Mechanisms of Action MoA:

• Eucalyptus spp plant blends:. Its anti-inflammatory properties contribute to soothing irritated gastrointestinal lining.  
• Phenanthrenequinone:. Due to its mechanisms involving oxidative stress generation and disruption of cellular processes, its use for antimicrobial effects against certain pathogens or in targeted therapies against cancer cells. In these specific, controlled contexts, its ability to induce cell damage might be leveraged to eliminate unwanted microbial growth or abnormal cell proliferation on the gastrointestinal lining.   
• Alpha-naphthol: 1-Naphthol (alpha-naphthol) is a phenolic compound that can exhibit antioxidant activity. It has been used in pharmaceutical compounds such as antiseptic medications.  
• Daidzein: Daidzein exhibits anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and enzymes such as TNF-α, IL-6, and COX-2. It also functions as a natural antioxidant, inhibiting lipid oxidation and improving the activity of anti-oxidative enzymes. These anti-inflammatory and antioxidant properties could contribute to soothing an irritated gastrointestinal tract, which is often a component of GERD and ulcers. Daidzein's anti-inflammatory properties directly address the inflammatory component of conditions like GERD and stomach ulcers. By inhibiting key pro-inflammatory mediators, it can help mitigate the discomfort and damage associated with these conditions.  
• Solasodine: Solasodine has powerful anticancer properties by inducing apoptosis and cell cycle arrest in various tumor cells. It suppresses proliferation and motility of colorectal cancer cells through inhibition of the AKT/GSK-3β/β-catenin signaling pathway.  
• Dodecanoic acid:. Its primary therapeutic role is antimicrobial. It can treat intestinal infections.  
• 6-Octadecenoic acid methyl ester: This compound, related to oleic acid, possesses antimicrobial and antibacterial activities. 
• Hexadecenoic acid methyl ester: This compound exhibits antimicrobial, antibacterial, anti-inflammatory, and antioxidant properties.   
• Methyl tetradecanoate:  Methyl tetradecanoate, or methyl myristate, primarily impacts gastrointestinal health indirectly. Upon ingestion, it is hydrolyzed in the gut to release methanol and tetradecanoic acid (myristic acid). The myristic acid then serves as a metabolic precursor, providing essential energy and building blocks for maintaining the health and integrity of gut epithelial cells, which are crucial for digestion and barrier function. Furthermore, the released myristic acid, and its derivative monomyristin, exhibit notable antimicrobial properties by disrupting microbial cell membranes, potentially helping to modulate the gut microbiota and inhibit the growth of undesirable bacteria and viruses, thereby contributing to a healthier gut environment.  

Table 7: Nsaale Antacid Herbal Syrup - Key Ingredients, Therapeutic Indications, and Mechanisms of Action

Key Ingredient	Primary Therapeutic Role in Product	Mechanism of Action (MoA)	Relevant Snippet IDs
Eucalyptus spp. plant blends	Anti-inflammatory, Analgesic	Modulates immune response; inhibits pro-inflammatory cytokines; analgesic effects; potential soothing effect on GI lining.
Phenanthrenequinone	Oxidative stress generation and disruption of cellular processes	Its ability to induce cell damage might be leveraged to eliminate unwanted microbial growth or abnormal cell proliferation on the gastrointestinal lining.
Alpha-naphthol	Antioxidant, Antiseptic	Phenolic compound with antioxidant activity; used in antiseptic medications. Help to neutralize Acid.
Daidzein	Anti-inflammatory, Antioxidant	Inhibits pro-inflammatory cytokines (TNF-α, IL-6, COX-2); natural antioxidant; inhibits lipid oxidation; improves anti-oxidative enzymes.
Solasodine	Anticancer	Induces apoptosis and cell cycle arrest in tumor cells; suppresses proliferation via AKT/GSK-3β/β-catenin pathway.
Dodecanoic acid	Antimicrobial (antibacterial, antiviral, antifungal)	Interferes with cell membranes; inhibits bacterial growth; can treat intestinal infections.
6-Octadecenoic acid methyl ester	Antimicrobial, Antibacterial	Possesses antimicrobial and antibacterial activities.
Hexadecenoic acid methyl ester	Antimicrobial, Antibacterial, Anti-inflammatory, Antioxidant	Exhibits antimicrobial, antibacterial, anti-inflammatory, and antioxidant properties.
Methyl tetradecanoate	Metabolic precursor	Providing essential energy and building blocks for maintaining the health and integrity of gut epithelial cells, which are crucial for digestion and barrier function.

8. Nsaale Dentalfix  NDA REG No. THA 1358

Therapeutic Indications: Nsaale Dentalfix helps relieve tooth decay, plaque, gingivitis, periodontitis, tooth sensitivity, oral thrush, cold sores, tooth erosion, and bad breath.  

Key Ingredients & Their Mechanisms of Action MoA:

• Linalool: Linalool possesses antibacterial and antifungal properties. It also acts on the inflammatory process and oxidative stress. These properties are beneficial for addressing gingivitis, periodontitis, oral thrush (fungal), and general oral infections.  
• Patchouli alcohol: Patchouli alcohol exhibits broad-spectrum antibacterial activity against both Gram-negative and Gram-positive bacteria, including drug-resistant strains like MRSA. It also has antiviral properties. Its antimicrobial effects are particularly relevant for plaque, gingivitis, periodontitis, and bad breath, which are often caused by bacterial imbalances. Patchouli alcohol's demonstrated broad-spectrum antibacterial and antiviral activity directly supports its role in addressing a wide range of oral health issues, from plaque and gingivitis (bacterial) to cold sores (viral). This provides a strong mechanistic basis for its inclusion in a dental product.  
• Dodecanoic acid methyl ester:. Its primary therapeutic role is antimicrobial (antibacterial, antiviral, antifungal), which is relevant for oral infections and plaque.  
• Hexadecanoic acid methyl ester:. Its primary therapeutic roles are antimicrobial, antibacterial, anti-inflammatory, and antioxidant, all beneficial for oral health.  
• Lauric acid (Dodecanoic acid):. Its primary therapeutic role is antimicrobial (antibacterial, antiviral, antifungal). It has strong bactericidal properties, especially against Gram-positive pathogenic bacteria, and interferes with cell membranes. This is highly relevant for combating oral pathogens.  
• Tonalid: Tonalid is a fragrance ingredient used to impart a pleasant, clean, or fresh musky scent to the product, masking less desirable base odors and enhancing the user's sensory experience, thereby encouraging product use.
• 6-Octadecenoic acid: This compound possesses antimicrobial and antibacterial activities. Its primary therapeutic roles are antimicrobial and antibacterial, which are beneficial for oral hygiene.  
• Daidzein:. Its anti-inflammatory and antioxidant properties  contribute to soothing inflamed gums (gingivitis, periodontitis).  
• Methyl stearate:. Its primary role is as an excipient, enhancing formulation and stability.  

Table 8: Nsaale Dentalfix - Key Ingredients, Therapeutic Indications, and Mechanisms of Action

Key Ingredient	Primary Therapeutic Role in Product	Mechanism of Action (MoA)	Relevant Snippet IDs
Linalool	Antibacterial, Antifungal, Anti-inflammatory, Antioxidant	Possesses antibacterial and antifungal properties; acts on inflammatory process and oxidative stress.
Patchouli alcohol	Broad-spectrum Antimicrobial (antibacterial, antiviral)	Exhibits broad-spectrum antibacterial activity against Gram-negative and Gram-positive bacteria (including MRSA); has antiviral properties.
Dodecanoic acid methyl ester	Antimicrobial (antibacterial, antiviral, antifungal)	Interferes with cell membranes; inhibits bacterial growth; can treat intestinal infections.
Hexadecanoic acid methyl ester	Antimicrobial, Antibacterial, Anti-inflammatory, Antioxidant	Exhibits antimicrobial, antibacterial, anti-inflammatory, and antioxidant properties.
Lauric acid (Dodecanoic acid)	Antimicrobial (antibacterial, antiviral, antifungal)	Strong bactericidal properties (especially against Gram-positive); interferes with cell membranes.
Tonalid	Fragrance properties	Impart a pleasant, clean, or fresh musky scent to the product.
6-Octadecenoic acid	Antimicrobial, Antibacterial	Possesses antimicrobial and antibacterial activities.
Daidzein	Anti-inflammatory, Antioxidant	Inhibits pro-inflammatory cytokines; natural antioxidant.
Methyl stearate	Excipient (Enhances Formulation, Stability)	Nonionic surfactant, emulsifier, and stabilizer.

9. Nsaale Nasalfree

Therapeutic Indications: Nsaale Nasalfree is a natural remedy extracted from Curcuma longa & Eucalyptus spp. It washes out and cleans the nasal canals physiologically, increasing sinus humidity and enabling normal respiration by relieving congestion caused by common cold, sinusitis, hay fever, and allergies. It is indicated for Rhinitis, Sinusitis, Common Cold, Nasal Polyps, and Anosmia.  

Key Ingredients & Their Mechanisms of Action MoA:

• Curcuma longa (Turmeric):. Its anti-inflammatory and antimicrobial properties are highly relevant for reducing inflammation in nasal passages and combating pathogens associated with colds and sinusitis. Turmeric supports healthy nasal passages.  
• Eucalyptus spp:. Eucalyptus oil is effective in reducing pain, swelling, and inflammation, and exhibits antibacterial and cough suppressant actions. It can be applied directly to the skin for nasal stuffiness. Its main component, 1,8-cineole, inhibits pro-inflammatory cytokines. These properties directly support its role in relieving nasal congestion and inflammation.  
• Dodecanoic acid:. Its primary therapeutic role is antimicrobial, which can help combat bacterial and viral infections contributing to nasal congestion.  
• Dodecanoic acid methyl ester:. Its primary therapeutic role is antimicrobial.  
• 1-Heptatriacotanol: This exhibit antimicrobial, antioxidant, and immunomodulatory properties.   
• Tetrapentacontane: Tetrapentacontane has demonstrated significant antimicrobial activity against pathogenic bacteria. It is also reported to have antioxidant and anti-inflammatory properties. Its antimicrobial properties contribute to addressing infections in the nasal passages.  
• Hexadecanoic acid methyl ester:. Its primary therapeutic roles are antimicrobial, antibacterial, anti-inflammatory, and antioxidant, which are beneficial for nasal health.  
• Pentadecanoic acid: Pentadecanoic acid is an essential odd-chain saturated fatty acid with broad activities relevant to protecting cardiometabolic, immune, and liver health. It activates AMPK and inhibits mTOR, core components of the human longevity pathway.  
• Methyl stearate:. Its primary role is as an excipient, enhancing formulation and stability.  
• Methyl tetradecanoate:. Its primary role is as a flavoring agent and fragrance. 

Table 9: Nsaale Nasalfree - Key Ingredients, Therapeutic Indications, and Mechanisms of Action

Key Ingredient	Primary Therapeutic Role in Product	Mechanism of Action (MoA)	Relevant Snippet IDs
Curcuma longa (Turmeric)	Anti-inflammatory, Antimicrobial, Antioxidant	Disrupts bacterial cell membranes; inhibits bacterial virulence factors; modulates host immune responses; supports healthy nasal passages.
Eucalyptus spp.	Anti-inflammatory, Antimicrobial, Analgesic, Decongestant	Modulates immune response; inhibits pro-inflammatory cytokines; exhibits antibacterial and cough suppressant actions; relieves nasal stuffiness.
Dodecanoic acid	Antimicrobial (antibacterial, antiviral, antifungal)	Interferes with cell membranes; inhibits bacterial growth.
Dodecanoic acid methyl ester	Antimicrobial (antibacterial, antiviral, antifungal)	Interferes with cell membranes; inhibits bacterial growth.
1-Heptatriacotanol	Antimicrobial, Antioxidant, Immunomodulatory	Exhibits antimicrobial, antioxidant, and immunomodulatory properties.
Tetrapentacontane	Antimicrobial, Antioxidant, Anti-inflammatory	Demonstrates significant antimicrobial activity; reported to have antioxidant and anti-inflammatory properties.
Hexadecanoic acid methyl ester	Antimicrobial, Antibacterial, Anti-inflammatory, Antioxidant	Exhibits antimicrobial, antibacterial, anti-inflammatory, and antioxidant properties.
Pentadecanoic acid	Immune Support, Metabolic Health	Activates AMPK and inhibits mTOR; relevant to protecting cardiometabolic, immune, and liver health.
Methyl stearate	Excipient (Enhances Formulation, Stability)	Nonionic surfactant, emulsifier, and stabilizer.
Methyl tetradecanoate	Flavoring Agent, Fragrance	Fatty acid methyl ester used as flavoring and fragrance.

10. Nsaale Herbal Cough Syrup

Therapeutic Indications: Nsaale Herbal Cough Syrup is indicated for the relief of coughs, chest congestion, and sore throats associated with respiratory infections.  

Key Ingredients & Their Mechanisms of Action MoA:

• Eucalyptus spp.: The volatile oils in eucalyptus, specifically eucalyptol (1,8-cineole), act as an expectorant by stimulating the respiratory tract's mucous glands. This increases fluid production, which thins and loosens mucus, making it easier to cough up and clear from the airways. It also reduces pain, swelling, and inflammation via immune modulation and exhibits antibacterial and cough suppressant actions. Eucalyptus's expectorant action directly addresses chest congestion by facilitating mucus clearance, while its anti-inflammatory and analgesic properties provide symptomatic relief for sore throats and general respiratory discomfort.  
• Curcuma Longa (Turmeric):. Its antimicrobial and anti-inflammatory properties are beneficial for combating respiratory pathogens and reducing inflammation in the respiratory tract, contributing to cough and congestion relief.  
• Musa x paradisiaca (Banana) extracts: Banana extracts, rich in mucilage, provide a soothing demulcent effect. They form a protective layer over irritated mucous membranes in the throat and respiratory tract, which helps relieve discomfort and reduce irritation. This demulcent action directly soothes irritated mucous membranes, providing immediate relief for sore throats and reducing the irritation that can trigger coughing.  
• Alisol F: Alisol F exhibits anti-inflammatory potential by inhibiting LPS-induced NO production in macrophages and regulating the production of inflammatory cytokines like TNF-α, IL-1β, and IL-6 via the MAPK/STAT3/NFκB pathway. This anti-inflammatory action is highly relevant for reducing inflammation associated with respiratory infections.  
• Dotriaconytl ethyl ether:  Dotriacontanyl ethyl ether, when used in a cough syrup, would primarily function as an emollient for the throat and respiratory passages. By forming a thin, stable film, it could help soothe irritation and provide a lubricating effect, reducing the friction that contributes to coughing. This physical barrier may also help to minimize moisture loss from the mucosal linings, which can alleviate dryness and provide a more comfortable sensation in the throat, potentially reducing the urge to cough. It does not act as a bronchodilator, expectorant, or cough suppressant that targets the cough reflex; its benefit is solely through its conditioning and protective properties on the irritated tissues.  
• Benzoic acid Silver 1+ salt: Benzoic acid is an antimicrobial food additive that is fungistatic and can bind amino acids, reducing ammonia levels. It is used in combination to treat oropharyngeal pain, mouth infections, throat infections, and dry cough. Its antimicrobial properties can help combat pathogens in the respiratory tract, and its analgesic effects contribute to sore throat relief.  
• Picolinyl 18-methyl 7 eicosenoate:  is a highly specialized molecule primarily recognized in analytical chemistry for its use in identifying the precise structure of complex fatty acids via mass spectrometry;  its potential to be hydrolyzed into its constituent fatty acid. This fatty acid, if released and absorbed, offer indirect support through its potential to integrate into cell membranes of respiratory tissues, influencing local immune responses or providing a very subtle emollient-like effect to soothe irritated mucosal linings.
• Propanoic acid: Propionic acid, a short-chain fatty acid, has anti-inflammatory and anti-proliferative properties. It modulates gene expression epigenetically by inhibiting histone deacetylases, affecting apoptosis, inflammation, and immune function. It has shown beneficial immunoregulatory and neuroprotective effects, boosting regulatory T cells and reducing pro-inflammatory responses. These anti-inflammatory and immunomodulatory effects are relevant for reducing respiratory tract inflammation.  
• N-methyladrenaline:  N-methyladrenaline, also known as epinephrine or adrenaline, functions as a potent neurotransmitter and hormone by binding to and activating various adrenergic receptors (α1​,α2​,β1​,β2​,β3​) found throughout the body. Upon binding, it triggers distinct intracellular signaling cascades via G proteins, leading to widespread physiological responses characteristic of the "fight or flight" mechanism. These effects include increased heart rate and contractility, vasoconstriction (in most vascular beds) or vasodilation (in skeletal muscle), bronchodilation, and glucose mobilization, all aimed at preparing the body for immediate action.
• Alanine, 4-(3-methoxyl): Alanine is a non-essential amino acid involved in sugar and acid metabolism, immunity, and energy for muscle tissue, brain, and central nervous system. It can be converted to glucose by the liver, playing a role in blood sugar balance. A derivative, Alanine, 3-(3-formyl-4-methoxyphenyl)-, hydrochloride, DL-, is used in pharmaceutical development. 
• 19-epoxyandrostane-8-9-dione: This compound has demonstrated anti-inflammatory, anti-apoptotic, and anti-infective properties. These properties are relevant for combating infections and reducing inflammation in the respiratory tract.  

Table 10: Nsaale Herbal Cough Syrup - Key Ingredients, Therapeutic Indications, and Mechanisms of Action

Key Ingredient	Primary Therapeutic Role in Product	Mechanism of Action (MoA)	Relevant Snippet IDs
Eucalyptus spp.	Expectorant, Anti-inflammatory, Antimicrobial, Cough Suppressant	Stimulates mucous glands to thin mucus; reduces pain, swelling, and inflammation; exhibits antibacterial and cough suppressant actions; inhibits pro-inflammatory cytokines.
Curcuma Longa (Turmeric)	Anti-inflammatory, Antimicrobial, Antioxidant	Combats respiratory pathogens; reduces inflammation in respiratory tract; supports healthy nasal passages.
Musa x paradisiaca (Banana) extracts	Demulcent	Forms a protective layer over irritated mucous membranes in throat and respiratory tract, relieving discomfort and irritation.
Alisol F	Anti-inflammatory	Inhibits LPS-induced NO production in macrophages; regulates inflammatory cytokines via MAPK/STAT3/NFκB pathway.
Dotriaconytl ethyl ether	Lubricating effect	Function as an emollient for the throat and respiratory passages. By forming a thin, stable film,  reducing the friction that contributes to coughing.
Benzoic acid Silver 1+ salt	Antimicrobial, Analgesic	Antimicrobial food additive; fungistatic; used for oropharyngeal pain, mouth/throat infections, dry cough.
Picolinyl 18-methyl 7 eicosenoate	Indirect support  in identifying the precise structure of complex fatty acids	Its potential to integrate into cell membranes of respiratory tissues, influencing local immune responses or providing a very subtle emollient-like effect to soothe irritated mucosal linings.
Propanoic acid	Anti-inflammatory, Immunomodulatory	Inhibits histone deacetylases; affects apoptosis, inflammation, and immune function; boosts regulatory T cells; reduces pro-inflammatory responses.
N-methyladrenaline	Adrenergic receptors	Functions as a potent neurotransmitter and hormone by binding to and activating various adrenergic receptors (α1​,α2​,β1​,β2​,β3​) found throughout the body.
Alanine, 4-(3-methoxyl)	General Metabolic/Immune Support	Involved in sugar/acid metabolism, immunity, energy provision; derivative used in pharmaceutical development.
19-epoxyandrostane-8-9-dione	Anti-inflammatory, Anti-infective	Exhibits anti-inflammatory, anti-apoptotic, and anti-infective properties.

User Instructions

 You must follow these instructions for quicker results;

1. Bath the whole body with Nsaale Herbal soap with Activated Charcoal at night and after smear the soap lather on the affected skin parts and leave it on until the next bath twice a day.

2. Bath the whole body with Nsaale Herbal Soap with Turmeric in the Morning and after smear the soap lather on the affected skin parts and leave it on until the next bath twice a day.

3. Spray Nsaale Antiseptic Solution on the affected skin parts twice a day. 

4. Smear the whole body with Nsaale Herbal Lotion including the affected skin parts twice a day.

5. Smear the affected parts with Nsaale Ointment twice a day. 

6. Take the prescribed dosage of Nsaale Body Detoxifier Bio- Syrup twice a day.

7. Drop 2 to 3 drops of Nsaale Nasalfree in each nostrils 3 times a day.

8. Take the prescribed dosage of Nsaale Antiacid Herbal Syrup twice a day. 

9. Take the prescribed dosage of Nsaale Herbal Cough Syrup 3 times a day.

10. Brush your teeth thoroughly with plain water and after brush with Nsaale Dentalfix and don't rinse afterwards twice a day.